2016-11-10 22:59:10 UTC

2017 James W. Freston Conference: Extracellular Vesicles — Biology, Translation and Clinical Application in GI Disorders


Sept. 9 and 10, 2017


Saint Paul, MN


Registration opens Feb. 1, 2017.

Cutting-edge research and innovative insight await you at the 2017 Freston conference. Join the foremost investigators in GI and extracellular vesicles to delve deeper into vesicle biogenesis and secretion — revealing its relevance to GI diseases and clinical applications.

Who Should Take this Course

This conference is ideal for basic and translational researchrs in GI biology and pathobiology.


Saturday, Sept. 9, 2017

7–8 a.m. Registration and Continental Breakfast
8–8:15 a.m. Welcome and Opening Remarks
Nicholas F. LaRusso, MD, AGAF

Session 1 — Discovery: Biogenesis and Secretion
Moderators: Nicholas F. LaRusso, MD, AGAF, and Harmeet Malhi, MBBS
8:15–9 a.m. Keynote Address: EV in GI Tumorigenesis
David Lyden, MD, PhD
9–9:30 a.m. Biogenesis, Secretion and Characterization of EV Population
Clotilde Thery, PhD
9:30–10 a.m. Protein Sorting into EV
Stephen Gould, PhD
10–10:30 a.m. Coffee Break

Session 2 — Discovery: Biogenesis and Secretion (Cont'd)
Moderators: Clotilde Thery, PhD, and Alissa Weaver, PhD
10:30–11 a.m. Cargo Sorting by KRAS into EV
Robert J. Coffey, MD
11–11:30 a.m. Lipids in EV Biogenesis
Harmeet Malhi, MBBS
11:30 a.m.–noon Domain-Specific Secretion of Exosomes from Polar Epithelia
Nicholas F. LaRusso, MD, AGAF
Noon–1:15 p.m. Interactive Lunch

Session 3 — Translation: Disease Relevance
Moderators: Robert J. Coffey, MD, and Gregory Gores, MD
1:15–1:45 p.m. Mechanisms of EV Released by Stressed Hepatocytes
Gregory Gores, MD
1:45–2:15 p.m. Immune Regulation by EV in Liver Disease Models
Gyongyi Szabo, MD, PhD
2:15–2:45 p.m. Bacteria-Derived Microvesicles in the Gut-Brain Axis
John Bienenstock, MD, FRCP
2:45–3:15 p.m. Coffee Break

Session 4 — Translation: Disease Relevance (Cont'd)
Moderators: David Lyden, MD, PhD, and Gyongyi Szabo, MD, PhD
3:15–3:45 p.m. EV in Obesity
Robert J. Freishtat, MD, MPH
3:45–4:15 p.m. EV Regulation of Directional Cell Migration
Alissa Weaver, MD, PhD
4:15–5 p.m. Young Investigator Talk
5–6:30 p.m. Interactive Poster Session

Sunday, Sept. 10, 2017

7–8 a.m. Registration and Continental Breakfast

Session 5 — Application: Diagnosis and Therapeutics
Moderators: Ariel E. Feldstein, MD, and John Bienenstock, MD, FRCP
8–8:30 a.m. EV miRNA: Liquid Biopsies for Disease Diagnosis
Tushar Patel, MBChB
8:30–9 a.m. EV in Epithelial Integrity and Wound Repair in the Gut
Asma Nusrat, MD
9–9:30 a.m. Diagnostic Utility of EV in Pancreatic Cancer
Raghu Kalluri, MD, PhD
9:30–10 a.m. Coffee Break

Session 6 — Application: Diagnosis and Therapeutics (Cont'd)
Moderators: Tushar Patel, MD, NMChB, and Asma Nusrat, MD
10–10:30 a.m. EV-Based Therapy in GI Disease
Huang-Ge Zhang, MD, PhD
10:30 11:15 a.m. Young Investigator Talk
11:15–11:45 a.m. TBD
Jim G. Patton, PhD
11:45 a.m.–12:15 p.m. Circulating EV-Based Molecular Diagnostic
Ariel E. Feldstein, MD
12:15–12:25 p.m. Closing Remarks
Nicholas F. LaRusso, MD, AGAF
Robert J. Coffey, MD
12:30–1:15 p.m. Lunch


Registration opens Feb. 1, 2017.

Register early to receive a significant discount and reserve your spot at the conference. Online registration ends Friday, Aug. 25, 2017. After this date, only on-site registrations will be permitted. Registrations made on site are subject to the availability of space.

  Early Bird*
(Feb. 1–June 14)
(June 14–Aug.25)
On Site
(Aug. 25–Sept.10)
AGA Member $380 $430 $530
Nonmember $480 $530 $630
AGA Member Trainee/Student $80 $130 $180

Not an AGA member?
Submit a completed membership application with your course registration and pay the AGA member rate. Nonmember trainees must complete the trainee certification form before registering.

*If applying for AGA membership, your application must be received no later than May 22, 2017, to qualify for the AGA member early rate.

**If applying for AGA membership, your application must be received no later than Aug. 14, 2017, to qualify for the AGA member standard rate.

Cancellation Policy
A refund (minus a $50 processing fee) will be given for cancellations received in writing on or before Friday, Aug. 25, 2017. Please send requests to AGA Member Relations via email (member@gastro.org), fax (301-272-1774) or mail (4930 Del Ray Avenue, Bethesda, MD 20814).

No cancellations will be accepted for refunds after Aug. 25, 2017. Refunds cannot be made for no shows.


Upon completion of this conference, participants will be able to:

  • Understand the mechanisms of extracellular vesicle biogenesis and secretion.
  • Learn the pathways utilized by extracellular vesicles to communicate with target cells.
  • Gain insight into novel research directions and the evolving progress of the extracellular vesicle research field.
  • Appreciate the role of extracellular vesicles in disease pathogenesis.
  • Recognize existing and potential clinical applications of extracellular vesicles as diagnostic tools.
  • Develop knowledge and awareness of the therapeutic possibilities of extracellular vesicles.

Traveling? Recommended Accommodations

The reservation deadline is Friday, Aug. 18, 2017. Room blocks have been reserved for attendees at the following hotel.

InterContinental Saint Paul Riverfront
11 East Kellogg Boulevard
Saint Paul, MN 55101

Room rate: $155 single/double per night, plus tax.

Make your reservation by calling 866-686-2867. Be sure to mention that you are attending the 2017 Freston conference to receive the discounted rate.

Reservations must be guaranteed with a major credit card equal to one night’s room and tax. Cancellations must be made 72 hours prior to arrival in order to avoid charges for the first night’s room and tax. Reservations may only be cancelled by calling the hotel directly at 800-424-6835 or 651-605-0197 and obtaining a cancellation number. No shows will be charged first night’s room and tax.

About the Instructors

Conference Chairs

Nicholas F. LaRusso, MD, AGAF
Mayo Clinic

Robert J. Coffey, MD
Vanderbilt University Medical Center


John Bienenstock, MD, FRCP
McMaster Brain-Body Institute at St. Joseph's Healthcare Hamilton

Ariel E. Feldstein, MD
University of California, San Diego
Rady Children's Hospital, San Diego
University of South Carolina

Robert J. Freishtat, MD, MPH
Children's National Medical Center

Gregory J. Gores, MD
Mayo Clinic

Stephen Gould, PhD
Johns Hopkins Medicine

Raghu Kalluri, MD, PhD
MD Anderson Cancer Center

David Lyden, MD, PhD
Weill Cornell Medicine

Harmeet Malhi, MBBS
Mayo Clinic

Asma Nusrat, MD
University of Michigan

Tushar Patel, MBChB
Mayo Clinic

James G. Patton, PhD
Vanderbilt University

Gyongyi Szabo, MD, PhD
University of Massachusetts Medical School

Clotilde Thery, PhD
Institute Curie, INSERM U932

Alissa Weaver, MD, PhD
Vanderbilt University

Huang-Ge Zhang, MD, PhD
University of Louisville

Contact Information

For questions regarding registration, contact AGA Member Relations by emailing member@gastro.org.

For program-related questions, email agacouncil@gastro.org or call 301-272-1601.