Sessile Serrated Adenomas Are High-Risk Lesions

July 30, 2010

Sessile serrated adenomas are associated with colorectal carcinomas that demonstrate high microsatellite instability. Currently, sessile serrated adenomas are managed clinically in a similar fashion to adenomatous polyps. According to data published in the American Journal of Surgical Pathology, sessile serrated adenomas are high-risk lesions, with 15 percent of the sessile serrated adenomas patients developing subsequent colorectal carcinomas or adenomatous polyps with high-grade dysplasia. This incidence is higher than that of the control hyperplastic polyps and adenomatous polyps patients, and would support close endoscopic follow-up in patients harboring sessile serrated adenomas. 

American Journal of Surgical Pathology; 2010: 34(7): 927-34

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