Gastroenterology Podcast May 2012: Hepatic Cell–Type Specific Gene Expression is a Better Predictor of HCV Treatment Outcome than IL28B Genotype
Cell-type specific expression patterns of hepatic interferon-stimulated genes (ISGs) and single nucleotide polymorphisms (SNPs) near the IL28B gene are associated with response to interferon-based therapy in patients with chronic hepatitis C virus (HCV) infection. A study in the May issue of Gastroenterology finds that cell-type–specific expression pattern of ISGs varies among patients with different IL28B genotypes and is a strong predictor of response to interferon-based treatment. Dr. Kuemmerle discusses these findings with author Dr. Jordan Feld of the University of Toronto; Plus, a rundown of top stories from this month's issue of GI and Hepatology News.
McGilvray I, Feld, J, Chen L. Hepatic Cell–Type Specific Gene Expression Better Predicts HCV Treatment Outcome Than IL28B Genotype. Gastroenterology 2012; May; 142(5): 1122-1131.e1
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