Expert Panel Updates EoE Consensus Recommendations

January 12, 2012

Eosinophilic esophagitis (EoE) is a clinico-pathologic condition of increasing recognition and prevalence. In 2007, a consensus recommendation provided clinical and histo-pathologic guidance for the diagnosis and treatment of EoE; however, only a minority of physicians use the 2007 guidelines, which require fulfillment of both histologic and clinical features. Since 2007, the number of EoE publications has doubled, providing new disease insight. Accordingly, a panel of 33 physicians with expertise in pediatric and adult allergy/immunology, gastroenterology and pathology conducted a systematic review of the EoE literature using electronic databases.

Important additions, which can be found in the Journal of Allergy and Clinical Immunology, include genetic underpinnings that implicate EoE susceptibility caused by polymorphisms in the thymic stromal lymphopoietin protein gene and the description of a new potential disease phenotype, PPI-responsive esophageal eosinophila.

Journal of Allergy and Clinical Immunology 2011: 128(1): 3-20.e6