Post-Menopausal Women Taking Indigestion Drugs at Increased Risk of Fracture
PPIs are one of the most common medicines used worldwide and are often used to treat heartburn and acid reflex. They can, however, inhibit the absorption of calcium, which leads to the increased risk of fractures. Post-menopausal women are 35 percent more likely to suffer hip fracture if they take PPIs. This figure increases to 50 percent if they are also current or former smokers. Several studies have already been carried out in response to the growing concerns between the long-term use of PPIs and the risk of hip fractures. However, these studies have been met with significant limitations. In a study published in the British Medical Journal, doctors concluded that the FDA wishes to revise labeling on these drugs. They stress the importance of evaluating the need for long-term use of PPIs among those with a history of smoking.
British Medical Journal 2012;344:e372
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