Postbiotics May Be Safe Alternative for IBD

June 07, 2012

Probiotics and their metabolic products, here called postbiotics, have been proposed as food supplements for a healthier intestinal homeostasis, and also as therapeutic aids in IBD, but with very little clinical benefit. This may be due to the lack of reliable preclinical models for testing the efficacy of different strains. According to a study in Gut, probiotics can have inflammatory activities in both healthy and IBD tissue. Valid preclinical data on proper model systems should therefore be obtained before specific probiotic strains enter the clinics, especially if administered during acute inflammatory responses. Postbiotics may be a safe alternative for the treatment of patients with IBD in the acute inflammatory phase.

Gut 2012; 61: 1007-1015

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