2013-03-19 13:11:40 UTC

A Dominant CD4+ T-Cell Response to <em>H. pylori</em> Reduces Risk for Gastric Disease in Humans

March 21, 2013

Publishing in Gastroenterology, Li Chen and colleagues report that the HLA-DRB1*1501-restricted immuno-dominant CD4+ T-cell response to neuraminyllactose-binding hemagglutinin 88-100, which is a conserved, H. pylori-specific colonization factor that is being investigated as an antigen for vaccination strategies, is associated with reduced risk of severe gastric diseases.

Immuno-dominance is an important feature of antiviral, antitumor and antibacterial cellular immune responses, but it is not well demonstrated in the immune responses against Helicobacter pylori (H. pylori). Antigen-specific CD4+ T cells protect mice against infection with H. pylori. Li Chen and colleagues investigated the immuno-dominant CD4+ T-cell response to neuraminyllactose-binding hemagglutinin (HpaA), which is a conserved, H. pylori-specific colonization factor that is being investigated as an antigen for vaccination strategies. Publishing in Gastroenterology, the researchers report that the HLA-DRB1*1501-restricted immuno-dominant CD4+ T-cell response to HpaA88-100 is associated with reduced risk of severe gastric diseases. Further study of these and other immuno-dominant CD4+ T-cell responses to H. pylori will provide insight into mechanisms of protective immunity and aid in vaccine design.

Gastroenterology 2013: 144(3): 591-600

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