2011-08-16 13:23:49 UTC

A Look at Therapies for <i>H. Pylori</i> Infection in Latin America

Aug. 19, 2011

Standard 14-day triple-drug therapy is preferable to five-day concomitant or 10-day sequential four-drug regimens as empiric therapy for Helicobacter pylori infection in diverse Latin American populations.

Evidence from Europe, Asia and North America suggests that standard three-drug regimens of a PPI plus amoxicillin and clarithromycin are significantly less effective for eradication of Helicobacter pylori (H. pylori) infection than are five-day concomitant and 10-day sequential four-drug regimens that include a nitroimidazole. These four-drug regimens also entail fewer antibiotic doses than do three-drug regimens, and thus could be suitable for eradication programs in low-resource settings. Few studies in Latin America have been done where the burden of H. pylori-associated diseases is high. Data published in the Lancet suggests that standard 14-day triple-drug therapy is preferable to five-day concomitant or 10-day sequential four-drug regimens as empiric therapy for H. pylori infection in diverse Latin American populations.

The Lancet 2011: 378(9790): 507-514

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