2013-03-05 14:44:38 UTC

<em>H. Pylori</em> Infection Influences Peptic Ulcer Bleeding in Low-Dose Aspirin Users

March 7, 2013

Publishing in Gastroenterology, Francis Chan and colleagues report that the long-term incidence of recurrent ulcer bleeding with low-dose aspirin use is low after Helicobacter pylori (H. pylori) infection is eradicated.

Current guidelines recommend testing for Helicobacter pylori (H. pylori) infection among users of low-dose aspirin who are at high risk for developing ulcers. However, it is not clear whether this strategy affects long-term risk of ulcer bleeding. Francis Chan and colleagues assessed the utility of testing low-dose aspirin users with a high risk of ulcer bleeding for H. pylori infection. Publishing in Gastroenterology, the researchers report that the long-term incidence of recurrent ulcer bleeding with low-dose aspirin use is low after H. pylori infection is eradicated. Low-dose aspirin users without current or past H. pylori infections who develop ulcer bleeding have a high risk of recurrent bleeding. Tests for H. pylori infection can be used to assign high-risk low-dose aspirin users to groups that require different gastroprotective strategies. 

Gastroenterology 2013: 144(3): 528-535

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