2013-03-19 13:28:23 UTC

Gender and Age Are Determinants of the Clinical Phenotype of PBC and Response to Ursodeoxycholic Acid

March 21, 2013

Reporting in Gastroenterology, Marco Carbone and colleagues conclude that among patients with primary biliary cirrhosis (PBC), response to ursodeoxycholic acid, treatment and symptoms are related to gender and age at presentation, with the lowest response rates and highest levels of symptoms in women presenting at younger than age 50.

Studies of primary biliary cirrhosis (PBC) phenotypes largely have been performed using small and selected populations. Study size has precluded investigation of important disease subgroups, such as men and young patients. Marco Carbone and colleagues used a national patient cohort to obtain a better picture of PBC phenotypes. Reporting in Gastroenterology, the researchers conclude that among patients with PBC, response to ursodeoxycholic acid, treatment and symptoms are related to gender and age at presentation; the lowest response rates and highest levels of symptoms appearing in women younger than age 50. Increased severity of fatigue in women is related to increased autonomic symptoms, making dysautonomia a plausible therapeutic target.

Gastroenterology 2013: 144(3): 560-569

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