2015-03-10 20:27:14 UTC

IL33 Initiates a Skewed Th2 Response to Injury and Infection

March 12, 2015

Publishing in Cellular and Molecular Gastroenterology and Hepatology, Jon N. Buzzelli and colleagues report that IL33 is highly expressed in the gastric mucosa and promotes the activation of T helper 2–cytokine–expressing cells.

Interleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently activates Th2 immunity. It may play a pivotal role during Helicobacter pylori infection. Publishing in Cellular and Molecular Gastroenterology and Hepatology, Jon N. Buzzelli and colleagues delineate the role of IL33 in the normal gastric mucosa and in response to gastropathy. They report that IL33 is highly expressed in the gastric mucosa and promotes the activation of T helper 2–cytokine–expressing cells. The loss of IL33 expression after prolonged H. pylori infection may be permissive for the T helper 1–biased immune response observed during H. pylori infection and subsequent precancerous progression.

Cellular and Molecular Gastroenterology and Hepatology 2015: 1(2): 203-221.e3

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