2015-03-10 20:27:14 UTC

IL33 Initiates a Skewed Th2 Response to Injury and Infection

March 12, 2015

Publishing in Cellular and Molecular Gastroenterology and Hepatology, Jon N. Buzzelli and colleagues report that IL33 is highly expressed in the gastric mucosa and promotes the activation of T helper 2–cytokine–expressing cells.

Interleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently activates Th2 immunity. It may play a pivotal role during Helicobacter pylori infection. Publishing in Cellular and Molecular Gastroenterology and Hepatology, Jon N. Buzzelli and colleagues delineate the role of IL33 in the normal gastric mucosa and in response to gastropathy. They report that IL33 is highly expressed in the gastric mucosa and promotes the activation of T helper 2–cytokine–expressing cells. The loss of IL33 expression after prolonged H. pylori infection may be permissive for the T helper 1–biased immune response observed during H. pylori infection and subsequent precancerous progression.

Cellular and Molecular Gastroenterology and Hepatology 2015: 1(2): 203-221.e3

More on Helicobacter pylori Infection

Effects of Community Screening for Helicobacter pylori: 13-Year Follow-Up Evaluation of a Randomized Controlled Trial

Oct. 22, 2017

This randomized clinical trial with 13 years of follow-up evaluation, designed to provide evidence on the effect of H pylori population screening, showed no significant long-term effect when compared with usual care in this low-prevalence area.

Submucosal Tumor of the Stomach With Drastic, Short-Term Changes in Morphology

Aug. 10, 2017

What caused the lesion in a man diagnosed with a submucosal tumor in the upper gastric corpus, to change to a reddish, semipedunculated tumor with blood oozing on the surface?

Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells

July 1, 2017

Cell surface adhesion molecule CD44 has been identified as a gastric cancer stem cell marker.