2012-07-24 12:27:54 UTC

Liver Stiffness Predicts Clinical Outcome in HIV/HCV

July 24, 2012

Liver stiffness predicts clinical outcome in HIV/hepatitis C virus-coinfected patients with compensated liver cirrhosis and provides additional prognostic information to that provided by the Child-Turcotte-Pugh score.

Researchers in Spain assessed the predictive value of liver stiffness, measured by transient elastography, for clinical outcome in HIV/hepatitis C virus (HCV)-coinfected patients with compensated liver cirrhosis.

The team found that 8 percent of patients with a baseline liver stiffness less than 40 kPa developed a decompensation versus 29 percent with liver stiffness 40 kPa or more. Factors independently associated with decompensation were Child-Turcotte-Pugh class B versus A, log-plasma HCV RNA load, hepatitis B virus coinfection and baseline liver stiffness.

Child-Turcotte-Pugh class B and previous exposure to HCV therapy were independently associated with liver-related death.

Hepatology 2012: 56(1): 228–238

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