2012-07-24 12:27:54 UTC

Liver Stiffness Predicts Clinical Outcome in HIV/HCV

July 24, 2012

Liver stiffness predicts clinical outcome in HIV/hepatitis C virus-coinfected patients with compensated liver cirrhosis and provides additional prognostic information to that provided by the Child-Turcotte-Pugh score.

Researchers in Spain assessed the predictive value of liver stiffness, measured by transient elastography, for clinical outcome in HIV/hepatitis C virus (HCV)-coinfected patients with compensated liver cirrhosis.

The team found that 8 percent of patients with a baseline liver stiffness less than 40 kPa developed a decompensation versus 29 percent with liver stiffness 40 kPa or more. Factors independently associated with decompensation were Child-Turcotte-Pugh class B versus A, log-plasma HCV RNA load, hepatitis B virus coinfection and baseline liver stiffness.

Child-Turcotte-Pugh class B and previous exposure to HCV therapy were independently associated with liver-related death.

Hepatology 2012: 56(1): 228–238

More on Cirrhosis

Blog: Special 15th Anniversary Collection from Clinical Gastroenterology and Hepatology

Oct. 11, 2017

Celebrate this milestone with a look back at landmark articles, commentaries and reviews. Read more on the AGA Journals blog.

Statin Use and Risk of Cirrhosis and Related Complications in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis

Oct. 11, 2017

Statin use is probably associated with lower risk of hepatic decompensation and mortality, and might reduce portal hypertension, in patients with CLDs.

Cirrhosis Presenting as Cutaneous Calciphylaxis

Oct. 11, 2017

A 73-year-old woman with a history of hypertension presented with a 3-month history of a painful, non-healing right calf ulcer and 2–3 weeks of painful, dusky purple patches on the right thigh.