2017-06-14 20:30:31 UTC

New Study Links Unsaturated Fats to Fatty Liver Disease

June 15, 2017

CMGH article adds new information to our understanding of metabolically unhealthy obesity.

The role of diet in “metabolically unhealthy obesity” — where obese individuals have liver steatosis, abnormal glucose tolerance and other metabolic abnormalities — is highly controversial, but important to understand in making national dietary recommendations and in counseling affected patients.

Publishing in Cellular and Molecular Gastroenterology and Hepatology (CMGH), Caroline C. Duwaerts, PhD, and colleagues studied liver steatosis in rats treated with diets that varied in macronutrient composition (carbohydrates from starch or sucrose, and fats from oleate or palmitate) but were otherwise identical, with the same calorie content and micronutrients. Surprisingly, they found that ingestion of starch and the monounsaturated fatty acid oleate led to the worst liver steatosis and adipose tissue inflammation, and that it mimicked the effects of a high fat “western diet.”

According to CMGH Associate Editor Rebecca G. Wells, MD, “this study is important because it used fats and carbohydrates in proportions similar to the average American diet, and because it specifically tested a saturated fat (palmitate) versus a monounsaturated fat (oleate). The work adds new information to our understanding of metabolically unhealthy obesity and should lead to additional studies focusing on dietary oleate and macronutrient concentration.”

Read the full study on the CMGH website.

More on Non-Alcoholic Fatty Liver Disease (NAFLD)

Blog: Special 15th Anniversary Collection from Clinical Gastroenterology and Hepatology

Oct. 11, 2017

Celebrate this milestone with a look back at landmark articles, commentaries and reviews. Read more on the AGA Journals blog.

Blog: Restricting Fructose to Reduce Fatty Liver Disease

Sept. 19, 2017

Researchers report that reducing dietary fructose decreases liver fat in children with obesity and metabolic syndrome. Read more in the AGA Journals blog.

Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis

Sept. 1, 2017

PDFF estimated by MRI scanners of different field strength and at different sites, accurately classifies grades and changes in hepatic steatosis when histologic analysis of biopsies is used as a reference.