2013-04-30 15:22:32 UTC

Prognostic Gene Expression Signature for Patients With Hepatitis C–Related Early-Stage Cirrhosis

May 2, 2013

Yujin Hoshida and colleagues report in Gastroenterology that a 186-gene signature used to predict outcomes of patients with hepatocellular carcinoma (HCC) is also associated with outcomes of patients with hepatitis C–related early-stage cirrhosis. This signature might be used to identify patients with cirrhosis in most need of surveillance and strategies to prevent the development of HCC.

Cirrhosis affects 1 to 2 percent of the world population and is the major risk factor for hepatocellular carcinoma (HCC). Hepatitis C cirrhosis–related HCC is the most rapidly increasing cause of cancer death in the U.S. Non-invasive methods have been developed to identify patients with asymptomatic early-stage cirrhosis, increasing the burden of HCC surveillance, but biomarkers are needed to identify patients with cirrhosis who are most in need of surveillance. Yujin Hoshida and colleagues investigated whether a liver-derived 186-gene signature previously associated with outcomes of patients with HCC is prognostic for patients with newly diagnosed cirrhosis but without HCC. Publishing in Gastroenterology, they report that a 186-gene signature used to predict outcomes of patients with HCC is also associated with outcomes of patients with hepatitis C–related early-stage cirrhosis. This signature might be used to identify patients with cirrhosis in most need of surveillance and strategies to prevent the development of HCC. 

Gastroenterology 2013: 144(5), 1024-1030

More on Cirrhosis

Attend the AGA Postgraduate Course for Practical, Take Home Information

Feb. 12, 2018

Join us on June 2-3 in Washington, D.C. This course is held in conjunction with Digestive Disease Week® (DDW) 2018.

Blog: Diagnosis, Pathogenesis and Treatment of Hepatorenal Syndrome in Patients With Cirrhosis

Jan. 30, 2018

New concepts and developments for diagnosis and assessment of renal function in patients with cirrhosis. Read more on the AGA Journals Blog.

Image Challenge: Cullen's Sign

Jan. 22, 2018

What caused a 56-year-old man with a previous history of cirrhosis to present with a large volume of ascites and periumbilical ecchymosis?