2013-04-30 15:22:32 UTC

Prognostic Gene Expression Signature for Patients With Hepatitis C–Related Early-Stage Cirrhosis

May 2, 2013

Yujin Hoshida and colleagues report in Gastroenterology that a 186-gene signature used to predict outcomes of patients with hepatocellular carcinoma (HCC) is also associated with outcomes of patients with hepatitis C–related early-stage cirrhosis. This signature might be used to identify patients with cirrhosis in most need of surveillance and strategies to prevent the development of HCC.

Cirrhosis affects 1 to 2 percent of the world population and is the major risk factor for hepatocellular carcinoma (HCC). Hepatitis C cirrhosis–related HCC is the most rapidly increasing cause of cancer death in the U.S. Non-invasive methods have been developed to identify patients with asymptomatic early-stage cirrhosis, increasing the burden of HCC surveillance, but biomarkers are needed to identify patients with cirrhosis who are most in need of surveillance. Yujin Hoshida and colleagues investigated whether a liver-derived 186-gene signature previously associated with outcomes of patients with HCC is prognostic for patients with newly diagnosed cirrhosis but without HCC. Publishing in Gastroenterology, they report that a 186-gene signature used to predict outcomes of patients with HCC is also associated with outcomes of patients with hepatitis C–related early-stage cirrhosis. This signature might be used to identify patients with cirrhosis in most need of surveillance and strategies to prevent the development of HCC. 

Gastroenterology 2013: 144(5), 1024-1030

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