2013-04-23 14:20:07 UTC

Resveratrol Improves Intrahepatic Endothelial Dysfunction and Reduces Hepatic Fibrosis and Portal Pressure in Cirrhotic Rats

April 25, 2013

Marco Di Pascoli and colleagues publish in the Journal of Hepatology that resveratrol, a polyphenol found in a variety of fruits, may be a useful dietary supplement in the treatment of portal hypertension in patients with cirrhosis.

Resveratrol, a polyphenol found in a variety of fruits, exerts a wide range of beneficial effects on the endothelium, regulates multiple vasoactive substances and decreases oxidative stress, factors involved in the pathophysiology of portal hypertension. Marco Di Pascoli and colleagues evaluated the effects of resveratrol on hepatic and systemic hemodynamics, hepatic endothelial dysfunction, and hepatic fibrosis in CCl4 cirrhotic rats. Publishing in the Journal of Hepatology, the researchers conclude that resveratrol administration reduces portal pressure, hepatic stellate cell activation and liver fibrosis, and improves hepatic endothelial dysfunction in cirrhotic rats, suggesting it may be a useful dietary supplement in the treatment of portal hypertension in patients with cirrhosis. 

Journal of Hepatology 2013: 58(5), 904-910

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