2017-12-08 15:32:35 UTC

Top Gut Microbiome Papers of 2017

Dec. 11, 2017

Members of the AGA Center for Gut Microbiome Research and Education’s scientific advisory board share some of the most notable microbiome-related papers published this year.

Members of the AGA Center for Gut Microbiome Research and Education’s scientific advisory board were asked to share what they thought were some of the most notable microbiome-related papers published during 2017. Here’s what they said:

Purna Kashyap, MBBS
This has been an awesome year for microbiome research and there are so many neat publications in the field. This first study highlights the role of amino acids in dysbiosis and association between disease severity, gut dysbiosis and bacterial production of free amino acids in patients with Crohn’s disease. They found a bacterial enzyme (urease) supports this amino acid synthesis which could become a therapeutic target in the future.

The second study I wanted to highlight provides a new paradigm as well as examples of how gut microbes can affect host physiology, via bacteria-encoded or bacteria-produced small molecules acting on host receptors such as G-protein coupled receptors, which are fairly ubiquitous, similar to the host produced endogenous ligands.

Geoffrey Preidis, MD, PhD
This fascinating article advances our understanding of how gut microbes influence body composition. The authors elegantly describe a molecular pathway by which bacteria modify the host's circadian rhythm to alter intestinal lipid uptake and metabolism.

Eugene B. Chang, MD, AGAF
Both of these papers address important issues in inflammatory bowel disease (IBD), including the multi-generational effects of the gut microbiota.

Jasmohan Bajaj, MD, AGAF
Our group is very proud to have published the first randomized controlled trial on fecal microbiota transplantation (FMT) to treat hepatic encephalopathy, which resulted in reduced hospitalizations and hepatic encephalopathy episodes in addition to improving brain function in HE patients over the course of six months.

Zain Kassam, MD, MPH
This paper provides a practical framework for clinicians just starting FMT but also shares pragmatic solutions to challenging intricacies of managing patients with recurrent C. difficile infection. The 5D FMT framework — Decision (selecting appropriate patient for FMT), Donor (selection and screening), Discussion (risk, benefits, alternatives), Delivery (selecting appropriate modality for FMT administration) and Discharge (counseling at discharge and follow-up) — is a simple yet powerful approach to ensuring FMT best practices.

This article originally appeared in AGA Microbiome Update, which was emailed to AGA members on Dec. 13, 2017.

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