AGA Institute GastroSlides Unit on Barrett’s Esophagus
This teaching unit consists of 298 images that review the epidemiology, pathogenesis, molecular biology and treatment of Barrett’s esophagus. This multimedia unit includes animations, endoscopic images, new techniques to detect metaplasia and dysplasia (e.g. chromoendoscopy and spectroscopy), histology, and videos demonstrating endoscopic ablation and endoscopic mucosal resection. The unit is divided into six sections:
- Diagnosis and epidemiology of Barrett’s esophagus. This section highlights the prevalence of Barrett’s esophagus, its association with different factors, and the anatomical landmarks and histological findings required for diagnosis.
- Pathogenesis of Barrett’s development. This section reviews normal esophageal physiology, and abnormalities in lower esophageal sphincter function, hiatal hernias and other abnormalities of the distal esophagus that are associated with the development of Barrett’s esophagus.
- Progression of epithelial metaplasia to neoplasia. This section highlights the molecular mechanisms underlying progression of Barrett’s epithelium to dysplasia and cancer, with descriptive histology of the grades of dysplasia and cancer. Endoscopic photographs of lesions suspicious for cancer within Barrett’s mucosa and molecular markers that are associated with progression to cancer are included.
- Screening and surveillance in Barrett’s esophagus. This section reviews the epidemiology of esophageal adenocarcinoma, clinical risk factors associated with progression of Barrett’s epithelium to dysplasia and cancer, and different modalities for screening and surveillance.
- Treatment of Barrett’s esophagus and adenocarcinoma. This section reviews medical treatment (including chemoprevention), surgery and various endoscopic modalities.
- Barrett`s cases.
About the Instructors
Prateek Sharma, MD
Director, Gastroenterology Fellowship Program
University of Kansas School of Medicine
Kansas City, MO
Gary Falk, MD, MS, AGAF
Professor of Medicine and Co-Director, GI
University of Pennsylvania Perelman School of Medicine
Division of Gastroenterology
John Goldblum, MD
Department of Anatomic Pathology
Cleveland Clinic Foundation
Richard Sampliner, MD, FASGE
Southern Arizona VA Health Care System
Rhonda Souza, MD
Baylor University Medical Center at Dallas and Baylor Scott and White Research Insitute
Kenneth Wang, MD
Professor of Medicine; Kathy and Russ Van Cleve Professor of Gastroenterology Research
Mayo Clinic College of Medicine
Chapel Hill, NC
Jerry Schoendorf, MAMS
Chapel Hill, NC
The content included in this GastroSlide set, Barrett’s Esophagus, was published on May 15, 2004. This slide set has not been updated since the date of publication and is provided “as is.” It is the learner's responsibility to evaluate the accuracy of any information found within these educational materials.
The intent of this series is to provide individual clinicians and educators with materials to use in their educational activities, such as lecturing at continuing medical education meetings and for self-education. AGA encourages all uses of GastroSlide materials consistent with this objective.
Materials are to be displayed in the same content and form as the original with no alterations unless approved by AGA. No materials may be reproduced for any purpose without written permission of AGA. Materials may only be used for educational purposes and may not be used to promote or advertise any pharmaceutical, medical device or organization.