2017-03-07 21:26:38 UTC

AGA Institute GastroSlides Unit on The Genetic and Molecular Basis of Gastrointestinal and Liver Diseases



This unit consists of more than 314 images that review advances in molecular biology and genetics and apply these concepts to understanding the epidemiology, pathogenesis, molecular mechanisms and treatment of gastrointestinal and liver diseases that have a defined genetic basis. Among other methods, this multimedia unit employs animated cartoons to explain complex biological phenomena and describe their relation to disease. These include signaling cascades leading to inflammation, cell proliferation and apoptosis. Specific disorders are used in the form of case histories to exemplify how hereditary and acquired genetic changes result in disease. Disorders that are considered in this context include cystic fibrosis, hemochromatosis, alpha 1-antitrypsin deficiency, Wilson’s disease, colon cancer, Crohn’s disease, hereditary pancreatitis and Barrett’s esophagus.

About the Instructors


Mark Sawicki, MD
UCLA School of Medicine
Los Angeles, CA

Stephen J. Pandol, MD
UCLA School of Medicine
Los Angeles, CA

James B. McGee, MD
University of Pittsburgh School of Medicine
Pittsburgh, PA

The authors thank Fred Gorelick, MD, professor of medicine and cell biology, Yale University School of Medicine, New Haven, CT, for providing some slides and reviewing this unit.


Jerry Schoendorf, MAMS
Chapel Hill, NC

Stan Coffman
Medical Illustrator
Chapel Hill, NC

Mark Coffman
Medical Illustrator
Chapel Hill, NC

Published Date and Terms of Use

The content included in this GastroSlide set, The Genetic and Molecular Basis of Gastrointestinal and Liver Diseases, was published on May 15, 2004. This slide set has not been updated since the date of publication and is provided “as is.” It is the learner's responsibility to evaluate the accuracy of any information found within these educational materials.

The intent of this series is to provide individual clinicians and educators with materials to use in their educational activities, such as lecturing at continuing medical education meetings and for self-education. AGA encourages all uses of GastroSlide materials consistent with this objective.

Materials are to be displayed in the same content and form as the original with no alterations unless approved by AGA. No materials may be reproduced for any purpose without written permission of AGA. Materials may only be used for educational purposes and may not be used to promote or advertise any pharmaceutical, medical device or organization.

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