2011-05-03 13:54:23 UTC

β-Catenin Alterations Associated with CRC Survival

May 6, 2011

Among obese patients only, activation of cadherin-associated protein β 1 is associated with better colorectal cancer-specific and overall survival.

Alterations of the WNT signaling pathway and cadherin-associated protein β 1 (CTNNB1 or β-catenin) have been implicated in colorectal carcinogenesis and metabolic diseases. Among obese patients only, activation of CTNNB1 was associated with better colorectal cancer (CRC)-specific and overall survival, according to a study published in the Journal of the American Medical Association. Post-diagnosis physical activity was associated with better CRC-specific survival only among patients with negative status for nuclear CTNNB1. These molecular pathological epidemiology findings suggest that the effects of alterations in the WNT-CTNNB1 pathway on outcome are modified by BMI and physical activity.

Journal of the American Medical Association 2011; 305(16): 1685-1694

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