2015-03-17 18:43:42 UTC

Risk Stratification of Patients With BE and LGD or Indefinite for Dysplasia

March 19, 2015

Prashanthi N. Thota and colleagues report in Clinical Gastroenterology and Hepatology that, in Barrett’s esophagus (BE) patients, prevalent low-grade dysplasia (LGD), male sex, multifocality and nodules were associated with higher risk for progression to esophageal adenocarcinoma.

In patients with Barrett’s esophagus (BE), low-grade dysplasia (LGD) is a risk factor for esophageal adenocarcinoma (EAC), progressing at variable rates. Patients at higher risk for progression could benefit from intervention. Prashanthi N. Thota and colleagues assessed rates of progression of LGD and indefinite for dysplasia (IND) and risk factors for progression to high-grade dysplasia (HGD) and EAC. Reporting in Clinical Gastroenterology and Hepatology, they find that, on the basis of a database analysis of patients with BE, prevalent LGD, male sex, multifocality and nodules were associated with higher risk for progression to EAC. Older age at LGD diagnosis, IND at index biopsy and shorter BE length were associated with regression. These findings help in risk stratification of patients with BE and LGD or IND.

Clinical Gastroenterology and Hepatology 2015: 13(3): 459-465.e1

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