2015-06-05 18:31:18 UTC

IBD Treatment

Clinical Snapshots

About

This AGA Clinical Snapshot is an executive summary of Dr. Sandborn's presentation during the 2015 AGA Spring Postgraduate Course at DDW® 2015 in Washington, DC.

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Takeaways

1. Understand near-term and intermediate-term potential treatment options for patients who are failing currently available immunosuppressive and biologic therapy.

2. Many patients fail biologic therapy with anti-TNF agents and anti-integrin therapy with vedolizumab (anti-α4β7 antibody), through a variety of mechanisms including primary non-response, secondary lost response, and intolerance.

3. Treatment options switching within and out of class with alternative selective anti-integrin agents, sphingosine 1 phosphate (S1P) receptor modulators, Janus kinase (JAK) inhibitors, anti-interleukin 12/23 and anti- IL 23, and Smad7 antisense.

About the Instructors

William J. Sandborn, MD, AGAF, University of California, San Diego

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What are the Future Selective Anti-integrin Therapies in Addition to the Currently Available Agent Vedolizumab for the Treatment of Ulcerative Colitis and Crohn’s Disease?

In addition to the approved agent vedolizumab, there are three selective anti-integrin agents in development, anti-MAdCAM1 (PF-00547, 659, Pfizer), etrolizumab (anti-β7, rhumab beta 7, Genentech), anti-α4β7 (AMG181, Amgen) …

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