Headlines from the 2018 Gastrointestinal Cancers Symposium
Jan. 24, 2018
Novel approaches for CRC screening, new treatment options for GI cancers, and more presented at the meeting, which is co-sponsored by AGA.
New to CGH! Audio Summaries
Jan. 3, 2018
In the first audio summary, Clinical Gastroenterology and Hepatology editor in chief Dr. Fasiha Kanwal summarizes January’s top articles.
How to Achieve High-Value Care in GI and Hepatology
Jan. 3, 2018
A new AGA article series in CGH provides guidance to help you efficiently manage your practice.
Digestive Disease Week® (DDW)
Dec. 19, 2017
Digestive Disease Week® (DDW) is the premier meeting for the GI professional. Every year it attracts approximately 15,000 physicians, researchers and academics from around the world who desire to stay up-to-date in the field.
Estrogen Replacement Reduces Risk and Increases Survival Times of Women With Hepatocellular Carcinoma
Oct. 22, 2017
In a case–control study of women with HCC vs female control subjects at a single center, we associated use of estrogen MHT with reduced risk of HCC and increased overall survival times of patients with HCC.
Blog: Special 15th Anniversary Collection from Clinical Gastroenterology and Hepatology
Oct. 11, 2017
Celebrate this milestone with a look back at landmark articles, commentaries and reviews. Read more on the AGA Journals blog.
Risk of Hepatocellular Cancer in HCV Patients Treated With Direct-Acting Antiviral Agents
Oct. 1, 2017
Among HCV-infected patients treated with DAAs, SVR is associated with a considerable reduction in the risk of HCC; however, the risk for HCC remained high in patients with cirrhosis at the time of SVR.
Case Clinic 1: A 61-Year-Old Woman Previously Treated for HCV Genotype 1a
Sept. 28, 2017
This case highlights how findings of resistance and advanced fibrosis affect HCV management as well as the importance of post-treatment surveillance for hepatocellular carcinoma.
Identification of the Consistently Altered Metabolic Targets in Human Hepatocellular Carcinoma
Sept. 1, 2017
We provide the first exposition of the consistently altered metabolic genes in HCC and show that these genes are potentially relevant targets for onward studies in preclinical and clinical contexts.
An Unusual Cause of Obscure Gastrointestinal Bleeding
Aug. 30, 2017
Why did bleeding persist in a man with a one-month history of intermittent tarry to bloody stool despite medical therapy?
Incidence and Determinants of HCC in AIH
Aug. 1, 2017
Dr. Aylin Tansel discusses her manuscript "Incidence and Determinants of Hepatocellular Carcinoma in Autoimmune Hepatitis: A Systematic Review and Meta-analysis" for the August issue of CGH. To view: http://bit.ly/2wiXgT6.
Genetic Features of Aflatoxin-Associated Hepatocellular Carcinoma
June 26, 2017
We identified specific genetic and mutation features of HCCs associated with aflatoxin exposure, including mutations in ADGRB1, compared to HCCs from general populations.
Association of Provider Specialty and Multi-disciplinary Care With HCC Treatment and Mortality
June 1, 2017
Drs. Marina Serper and David E. Kaplan discuss their manuscript "Association of Provider Specialty and Multi-disciplinary Care With Hepatocellular Carcinoma Treatment and Mortality," for the June 2017 issue of Gastroenterology. To view manuscript click here http://bit.ly/2qkpCc5.
Association of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality
June 1, 2017
We investigated patient, provider, and health system factors associated with receipt of active HCC therapy and overall survival.
Bioinformatic Search Identifies Tapeworm Drug for Treatment of Hepatocellular Carcinoma
May 31, 2017
Niclosamide identified as a potential anti-tumor agent by researchers. Read more on the AGA Journals Blog.
New Hepatitis C Treatment Not Linked to Liver Cancer
May 25, 2017
Contrary to some earlier research, most recent studies see no association between response to DAAs and HCC.
Hepatocellular Carcinoma Is the Most Common Indication for Liver Transplantation and Placement on the Waitlist in the United States
April 29, 2017
HCC was the leading indication for liver transplantation in the United States in 2015.
A Deep Dive Into the Different Types of Liver Cancer
March 28, 2017
A Gastroenterology review article discusses different hypotheses about the cells responsible for liver tumorigenesis. Find out more on the AGA Journals Blog.
More Funding Needed in Fight Against Deadliest Cancers
March 8, 2017
AGA calls on Congress to increase NIH funding to $34 billion in FY 2017.
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation
March 1, 2017
We aimed to update the classification system for HCA and associate the subtypes with disease risk factors and complications.
Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012
March 1, 2017
In an analysis of the incidence of HCC in all 50 US states, we found the rate of increase in HCC to have slowed from 2010 through 2012.
A Case of Rosai-Dorfman Disease Masquerading as Cholangiocarcinoma
Feb. 28, 2017
The AGA Journals Blog recaps this challenging case published in CGH.
Mailed Outreach Program Increases Ultrasound Screening of Patients With Cirrhosis for Hepatocellular Carcinoma
Feb. 1, 2017
In a prospective study, we found outreach strategies to double the percentage of patients with cirrhosis who underwent ultrasound screening for HCC.
Natural History of Untreated Hepatocellular Carcinoma in a US Cohort and the Role of Cancer Surveillance
Feb. 1, 2017
Patients with HCCs, including those detected through surveillance, survived for short time periods in the absence of treatment, irrespective of their initial stage at diagnosis.
How Can We Study Genetic Heterogeneity Within Hepatocellular Carcinomas?
Jan. 3, 2017
Gastro researchers have developed a patient-derived cell line-based model to study how intratumor heterogeneity affects sensitivity of HCC to different therapeutic agents.
Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents
Jan. 2, 2017
We performed genetic analyses of different regions of HCCs to evaluate levels of intratumor heterogeneity and associate alterations with responses to different pharmacologic agents.
Arterial-Portal Fistula After Percutaneous Liver Biopsy in Hepatic Allograft Causing Hemobilia and Pancreatitis
Jan. 2, 2017
A 59-year-old man with HCV infection and HCC presented with acute onset epigastric pain and melena.
Highlighted Abstracts from the International Digestive Disease Forum
Dec. 21, 2016
CGH features 104 abstracts from the 2016 meeting, which took place in Hong Kong.
Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma
Nov. 25, 2016
In a randomized phase 2 study of patients with HCC of BCLC stages A or B, we found Y90 radioembolization to provide significantly longer TTP than cTACE.
Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma
Nov. 24, 2016
Dr. Riad Salem discusses his manuscript "Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma." To view abstract click http://bit.ly/2gRHzP7.
Association Between Level of Fibrosis, Rather Than Antiviral Regimen, and Outcomes of Patients With Chronic Hepatitis B
Oct. 25, 2016
We performed an analysis to investigate whether entecavir can reduce risk of HCC in patients with chronic HBV.
Unusual Cause of an Umbilical Nodule
Sept. 27, 2016
A 48-year-old man with chronic hepatitis B (but was not regularly followed up) was diagnosed with hepatocellular carcinoma.
Regulation of Transdifferentiation and Retrodifferentiation by Inflammatory Cytokines in Hepatocellular Carcinoma
Sept. 27, 2016
The signaling network that connects inflammation with retrodifferentiation could identify new therapies that are effective against highly heterogeneous tumors.
A Forward Genetic Screen Identifies Suppressors of Hepatocellular Carcinogenesis
Aug. 29, 2016
Gastroenterology researchers identified and validated 27 genes as suppressors of HCC. Read more on the AGA Journals Blog.
A Rare Hepatic Tumor Mimicking Hepatocellular Carcinoma in a Patient With Hepatitis C Cirrhosis
Aug. 23, 2016
A 55-year-old woman was seen in consultation for evaluation of a focal liver lesion.
Building Effective Quality Improvement Programs for Liver Disease: A Systematic Review of Quality Improvement Initiatives
Aug. 23, 2016
Past experience with QI provides generalizable rules for successful future interventions aimed at improved quality indicator adherence and patient outcomes.
Share Your Thoughts on Quality Measures That Will Work for You
Aug. 16, 2016
It's important that AGA-developed quality measures meet the needs of practicing GIs and hepatologists.
Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma
Aug. 1, 2016
We identified members of the Ral guanosine triphosphatase–activating protein pathway and other proteins as suppressors of HCC cell proliferation and tumor growth.
A Rare Cause of Ischemic Colitis
July 18, 2016
A 60-year-old man with a history of liver transplant 1 year prior, secondary to hepatitis C and hepatocellular carcinoma, presented with a 1-month history of abdominal pain.
Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
June 1, 2016
We investigated the roles of TANs in progression of hepatocellular carcinoma (HCC) using cell lines and immune cells isolated from patients.
Role of the GALAD and BALAD-2 Serologic Models in Diagnosis of Hepatocellular Carcinoma and Prediction of Survival in Patients
June 1, 2016
GALAD and BALAD-2 are statistical models for estimating the likelihood of the presence of hepatocellular carcinoma (HCC) in individual patients with chronic liver disease and the survival of patients with HCC, respectively.
10 Insights Into Why Patients with Cirrhosis Get Readmitted
April 19, 2016
CGH study offers insight into hospital readmission for cirrhosis patients and provides several important lessons for programs aimed at curbing readmissions.
Make GI Cancer Research a Top Priority for the National Cancer Moonshot Initiative
April 18, 2016
NCI opens online platform to submit ideas about research for Cancer Moonshot; submit your ideas for GI cancer research.
DDSEP 8 - Question Bank Only
April 12, 2016
Assess your knowledge with more than 800 questions, answers and rationales.
Effects of Alcohol Consumption on Hepatocarcinogenesis in Japanese Patients With Fatty Liver Disease
March 28, 2016
We aimed to investigate the influence of alcohol consumption on hepatocellular carcinoma in Japanese patients with FLD without viral hepatitis.
Variable Intra-Tumor Genomic Heterogeneity of Multiple Lesions in Patients With Hepatocellular Carcinoma
March 28, 2016
Sequence analysis of a single lesion cannot completely characterize the genomic features of HCC in some patients.
A Variant in PNPLA3 Associated With Fibrosis Progression but not Hepatocellular Carcinoma in Patients With Hepatitis C Virus Infection
Jan. 21, 2016
We evaluated the association between this SNP in PNPLA3 and fibrosis progression and development of HCC among HCV-infected patients.
Abdominal Splenosis Mimicking a Liver Mass: Diagnosis by EUS-FNA
Jan. 21, 2016
A 35-year-old woman was referred for evaluation of a hepatic mass discovered on imaging for abdominal pain.
Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease
Jan. 21, 2016
We investigated risk factors for development of HCC in the absence of cirrhosis in a U.S. population.
Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease
Jan. 21, 2016
Dr. Sahil Mittal discusses his manuscript "Hepatocellular Carcinoma in the Absence of Cirrhosis in United States Veterans Is Associated With Nonalcoholic Fatty Liver Disease." To view abstract click http://bit.ly/1SkIsKO.
Association Between Transjugular Intrahepatic Portosystemic Shunt and Survival in Patients With Cirrhosis
Jan. 21, 2016
We investigated whether a TIPS is associated with survival in patients with cirrhosis awaiting liver transplantation.
High-Dose Radiation Can Improve IHCC Survival
Dec. 15, 2015
Dr. Randa Tao and colleagues studied inoperable intrahepatic cholangiocarcinoma patients from 2002 to 2014.
What Causes HCC When Cirrhosis Is Not a Factor?
Nov. 9, 2015
CGH research suggests NAFLD and metabolic syndromes are the biggest risk factors in the absence of cirrhosis.
The Art and Science of Managing Liver Disease
Oct. 22, 2015
Special CGH issue fills knowledge gap in clinical aspects of liver disease.
New Issue of AGA's Basic and Translational Science Journal
Sept. 11, 2015
The September issue of CMGH is now available. Read and submit your research.
New DNA Testing for Liver Cancer Could Improve Survival
Sept. 10, 2015
CMGH researchers uncover biomarker to predict severity of hepatocellular carcinoma.
Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy
Sept. 1, 2015
The presence of ctDNA reflects tumor progression, and detection of ctDNA can predict VP and recurrence.
Comparison of Liver Transplant–Related Survival Benefit in Patients With Versus Without Hepatocellular Carcinoma in the United States
Aug. 27, 2015
We compared patients who received liver transplants, with and without HCC, with regard to transplantation-related survival benefit.
Acute Anemia in a Patient With Hepatocellular Carcinoma
Aug. 27, 2015
A 64-year-old man presented with syncope.
AGA Institute-AASLD GastroSlides Unit on Liver Cancer
Aug. 6, 2015
GastroSlides images cover a number of GI and liver disease topics. Includes 264 images that illustrate epidemiological trends, causes, pathogenesis, screening, diagnosis and management of liver cancer.
Abdominal Distension in a Patient With Hepatocellular Carcinoma
July 27, 2015
A 71-year-old man with chronic hepatitis B-related liver cirrhosis and hepatocellular carcinoma was brought to the emergency department because he had experienced progressive abdominal distension for 1 week.
Management of Hepatocellular Adenoma: Recent Advances
June 23, 2015
Hepatocellular adenoma (HCA) is a rare benign liver cell neoplasm that occurs more frequently in young women with a history of prolonged use of oral contraceptives. Surgical resection is considered because of the risk of hemorrhage in 25% and of malignant transformation in 5% of patients with HCA.
Congenital Anomaly Detected During Work-up of Cystic Pancreatic Lesion
June 22, 2015
A 60-year-old man presented with mildly elevated liver function tests and a 4.4-cm cystic lesion in the uncinate process of the pancreas.
Obesity Early in Adulthood Increases Risk but Does Not Affect Outcomes of Hepatocellular Carcinoma
June 19, 2015
We performed a case–control study to investigate whether obesity early in adulthood affects risk, age of onset, or outcomes of patients with HCC.
Editors' Picks from June Journals
June 1, 2015
The CGH and Gastro editors share their lists of must-read articles from the June issues of the journals.
Evaluation of Early-Stage Hepatocellular Carcinoma by Magnetic Resonance Imaging With Gadoxetic Acid Detects Additional Lesions and Increases Overall Survival
June 1, 2015
Dr. Hyung-Don Kim discusses his manuscript.
Evaluation of Early-Stage Hepatocellular Carcinoma by Magnetic Resonance Imaging With Gadoxetic Acid Detects Additional Lesions and Increases Overall Survival
June 1, 2015
We investigated whether MR imaging with gadoxetic acid increases overall and recurrence-free survival of patients initially assessed by computed tomography.
A Polymorphism in Interferon L3 Is an Independent Risk Factor for Development of Hepatocellular Carcinoma After Treatment of Hepatitis C Virus Infection
May 1, 2015
There is controversy regarding how polymorphisms in IFNL3 affect the risk for development of hepatocellular carcinoma (HCC) in patients treated with pegylated interferon and ribavirin.
Top Picks from May CGH, Gastro
April 21, 2015
Drs. Hashem B. El-Serag and M. Bishr Omary share their top picks from the May issues of CGH and Gastro.
Unique Genomic Profile of Fibrolamellar Hepatocellular Carcinoma
April 1, 2015
We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors.
Temporal Trends of Nonalcoholic Fatty Liver Disease–Related Hepatocellular Carcinoma in the Veteran Affairs Population
March 1, 2015
We examined temporal trends, HCC surveillance practices, and outcomes of NAFLD-related HCC.
Tumor-Associated Macrophages Promote Expansion of Human HCC Stem Cells
Dec. 9, 2014
Publishing in Gastroenterology, Shanshan Wan and colleagues find that CD44+ cells isolated from human hepatocellular carcinoma (HCC) tissues and cell lines have cancer stem cells activities in vitro and form a larger number of xenograft tumors in mice than CD44- cells.
Hematochezia From Metastasis of Hepatocellular Carcinoma to Colon in a Patient Who Underwent Liver Transplantation
Sept. 5, 2014
Implementation of MELD Exception Points Increases Long-Term Survival Among HCC Patients
Sept. 4, 2014
Reporting in Clinical Gastroenterology and Hepatology, Robert J. Wong and colleagues find that patients with hepatocellular carcinoma (HCC) who met Milan criteria had significantly longer survival times after implementation of the Model for End-Stage Liver Disease (MELD) exception points, regardless of sex or ethnicity.
Primary Liver Cancer: Hepatocellular Carcinoma and Cholangiocarcinoma
Aug. 17, 2014
Discuss the diagnosis and management of hepatocellular carcinoma and cholangiocarcinoma
Post-Treatment Levels of a-Fetoprotein Predict Incidence of HCC After Interferon Therapy
July 17, 2014
Reporting in Clinical Gastroenterology and Hepatology, Tsugiko Oze and colleagues find that, in patients with chronic hepatitis C virus (HCV) infection, levels of α-fetoprotein decrease during interferon therapy, which predicts hepatocellular carcinoma (HCC).
Development of Hong Kong Liver Cancer Staging System With Treatment Stratification for Patients With Hepatocellular Carcinoma
June 11, 2014
PET-CT Imaging for CRC Patients With Hepatic Metastases
May 22, 2014
Reporting in JAMA, Carol-Anne Moulton and colleagues find that, among patients with potentially resectable hepatic metastases of colorectal adenocarcinoma, the use of positron emission tomography combined with CT (PET-CT) compared with CT alone did not result in frequent change in surgical management.
Antiviral Therapy for Chronic HBV Infection Is Associated with Reduced Risk of HCC
May 15, 2014
Publishing in Clinical Gastroenterology and Hepatology, Stuart C. Gordon and colleagues report that antiviral therapy for chronic hepatitis B virus (HBV) infection was associated with a reduced risk for hepatocellular carcinoma (HCC).
Activating Mutations in PTPN3 Promote Cholangiocarcinoma Cell Proliferation and Migration and Are Associated With Tumor Recurrence in Patients
May 2, 2014
Antiviral Therapy for Chronic Hepatitis B Virus Infection and Development of Hepatocellular Carcinoma in a US Population
May 2, 2014
Isolated Metastasis of Hepatocellular Carcinoma in the Right Ventricle
April 1, 2014
Understand the Newest Approaches for Treating Hepatitis C
Feb. 20, 2014
Register today for the 2014 AGA Spring Postgraduate Course to learn new and alternative approaches to treating common GI conditions, including hepatitis C.
Liver Stiffness Can Determine Risk Level in Patients with CLDs
Dec. 5, 2013
Reporting in Clinical Gastroenterology and Hepatology, Siddharth Singh and colleagues find that the degree of liver stiffness is associated with risk of decompensated cirrhosis, hepatocellular carcinoma and death in patients with chronic liver diseases (CLDs).
Coffee Reduces Risk for HCC
Oct. 24, 2013
Francesca Bravi and colleagues report in Clinical Gastroenterology and Hepatology that the risk of hepatocellular carcinoma (HCC) is reduced by 40 percent for any coffee consumption vs. no consumption.
Eradication of HCV and the Development of HCC
Aug. 8, 2013
Reporting in Annals of Internal Medicine, Rebecca L. Morgan and colleagues find that sustained virologic response after treatment among hepatitis C virus (HCV)-infected persons at any stage of fibrosis is associated with reduced hepatocellular carcinoma (HCC).
HCC 5-Gene Score Associated With Survival of Patients After Liver Resection
July 18, 2013
Reporting in Gastroenterology, Jean–Charles Nault and colleagues find that the molecular 5-gene score is associated with outcomes of patients with hepatocellular carcinomas (HCC) treated by resection in different clinical settings worldwide. This new biomarker should be tested in clinical trials to stratify patients in therapeutic decisions.
Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma
June 20, 2013
Reporting in the New England Journal of Medicine, Kol Jia Yong and colleagues find that the absence of SALL4 expression in the healthy adult liver enhances the potential of SALL4 as a treatment target in hepatocellular carcinoma.
CGH and Gastro Editors' Picks
June 13, 2013
The editors of Gastroenterology and Clinical Gastroenterology and Hepatology (CGH) would like to share their top picks from the June issues of the journals.
Dyspnea and Shoulder Pain in a Patient With Hepatocellular Carcinoma
May 30, 2013
The Clinical Gastroenterology and Hepatology image of the month showcases a 36-year-old man diagnosed with hepatitis B–related hepatocellular carcinoma and experiencing dyspnea and shoulder pain.
Gastroenterology Podcast May 2013: Hepatocellular Benign Tumors - Classification and Care
May 3, 2013
Prognostic Gene Expression Signature for Patients With Hepatitis C–Related Early-Stage Cirrhosis
May 2, 2013
Yujin Hoshida and colleagues report in Gastroenterology that a 186-gene signature used to predict outcomes of patients with hepatocellular carcinoma (HCC) is also associated with outcomes of patients with hepatitis C–related early-stage cirrhosis. This signature might be used to identify patients with cirrhosis in most need of surveillance and strategies to prevent the development of HCC.
Statins Are Associated with a Reduced Risk of Hepatocellular Cancer
Feb. 21, 2013
Based on meta-analysis performed by Siddharth Singh and colleagues and published in Gastroenterology, statin use is associated with a reduced risk of hepatocellular carcinoma, most strongly in Asian but also in Western populations.
CGH Image of the Month
Feb. 7, 2013
Synchronous Mandibular and Giant Parieto-Occipital Skull Metastasis From Hepatocellular Carcinoma
A 79-year-old man affected by multiple, well-differentiated hepatocellular carcinomas (HCCs) presented four months after transarterial chemo-embolization with a rapidly growing scalp mass of approximately 5 × 6 cm, associated with a smaller nodular lesion of the right parotid space (Figure A). His serum α-fetoprotein level was 11.4 ng/mL.
Nucleoside Analogues Lower HBV-Related HCC Risk
Nov. 29, 2012
In a study in the Journal of the American Medical Association, Wu et al. found that nucleoside analogue use was associated with a lower risk of hepatocellular carcinoma recurrence among patients with hepatitis B virus-related hepatocellular carcinoma after liver resection.
House Panel Passes Legislation to Increase Research for Pancreatic Cancer
Sept. 13, 2012
AGA is pleased that the House Energy and Commerce Subcommittee on Health passed legislation which will help provide a framework for the most deadly cancers, such as pancreatic, esophageal, stomach and liver.
Liver Disease Stage Associated with Antiviral Therapy
Aug. 2, 2012
Study results suggest that hepatic fibrosis stage is independently associated with a composite outcome of end-stage liver disease, hepatocellular carcinoma or death.
The Hepatologist’s Role in Prescribing Therapy for HCC
June 1, 2012
Should We Routinely Do Liver Biopsy in NAFLD Patients?
May 23, 2012
Transient Ischemic Attack in a Patient With Cirrhosis
Feb. 9, 2012
A Fishy Nodule
Jan. 23, 2012
Controversies in Hepatocellular Carcinoma Screening
Dec. 13, 2011
Nominations Open: Council Section Research Mentor Awards
Oct. 21, 2011
The deadline to submit your nominations is Dec. 15. We encourage you to forward information about the award to individuals you think might be interested.
Nominations Open for Council Section Research Mentor Awards
Oct. 15, 2011
The deadline to submit your nominations is Dec. 15. We encourage you to forward information about the award to individuals you think might be interested.
Hepatitis B Treatment Is Forever
Oct. 7, 2011
Radiographic Response to Locoregional Therapy in Hepatocellular Carcinoma Predicts Patient Survival Times
Aug. 8, 2011
Gastroenterology Podcast June 2011: Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease
June 1, 2011
FDA Approves Two New Hep C Drugs
May 27, 2011
This month, the FDA approved two new drugs for treating viral hepatitis C: Incivek (telaprevir) and Victrelis (boceprevir). These drugs represent a significant advance in treating this important infection, which is a major cause of cirrhosis, end-stage liver disease, liver transplantation and hepatocellular carcinoma.
MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a
May 2, 2011
A Rare Cause of Bloody Stools in a 57-Year-Old Woman With Hepatocellular Carcinoma
Feb. 8, 2011
An Unusual Case of a “Hepatic” Tumor
Feb. 8, 2011
Radioembolization Results in Reduced Toxicity in HCC Patients
Jan. 31, 2011
A novel approach to radiation therapy resulted in longer time to progression and less toxicity than standard of care treatment for hepatocellular carcinoma.
Few HCV-Infected Veterans Receive HCC Surveillance
Jan. 25, 2011
Doctors suggest that new strategies are needed to improve the implementation of hepatocellular carcinoma surveillance in clinical practice.
Changes in Digestive Disease Week® for 2011
Jan. 13, 2011
The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2
Jan. 10, 2011
An Aged Man With Massive Hepatosplenomegaly
Nov. 4, 2010
Akt Phosphorylation of Deleted in Liver Cancer 1 Abrogates Its Suppression of Liver Cancer Tumorigenesis and Metastasis
Oct. 4, 2010
C/EBP? Is Up-regulated in a Subset of Hepatocellular Carcinomas and Plays a Role in Cell Growth and Proliferation
July 28, 2010
Should We Screen for Hepatocellular Carcinoma in Patients with Cirrhosis? If So, in Whom and How?
July 6, 2010
Intermediate Hepatobiliary Cells Predict an Increased Risk of Hepatocarcinogenesis in Patients With Hepatitis C Virus-Related Cirrhosis
June 30, 2010
Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death
May 1, 2010
Induction of p53 Renders ATM-Deficient Mice Refractory to Hepatocarcinogenesis
April 15, 2010
Des-gamma-Carboxy Prothrombin and alpha-Fetoprotein as Biomarkers for the Early Detection of Hepatocellular Carcinoma
Feb. 1, 2010
Gastroenterology Podcast January 2010: Radioembolization for Hepatocellular Carcinoma Using Yttrium-90 Microspheres
The Clinical Gastroenterology and Hepatology image of the month showcases a 36-year-old man diagnosed with hepatitis B–related hepatocellular carcinoma and experiencing dyspnea and shoulder pain.
Synchronous Mandibular and Giant Parieto-Occipital Skull Metastasis From Hepatocellular Carcinoma
This month, the FDA approved two new drugs for treating viral hepatitis C: Incivek (telaprevir) and Victrelis (boceprevir). These drugs represent a significant advance in treating this important infection, which is a major cause of cirrhosis, end-stage liver disease, liver transplantation and hepatocellular carcinoma.